Raised in the African bush country by her zoologist parents, Cady Heron (Lindsay Lohan) thinks she knows about ‘survival of the fittest.’ But the law of the jungle takes on a whole new meaning when the home-schooled 15-year-old enters public high school for the first time and falls prey to the psychological warfare and unwritten social rules that teenage girls face today. Enter the ‘Queen Bee,’ the cool and calculating Regina George (Rachel McAdams) along with her sidekicks, best friends and devoted followers; Gretchen Weiners (Lacey Chabert, Party of Five) and Karen Smith (Amanda Seyfried). Together the three make up The Plastics, the most feared, revered and ultra-fashionable clique at North Shore. Rounding out the ensemble are witty social outcasts and art freak Janis Ian (Lizzy Caplan) and Out and Proud Damian (Daniel Franzese, Party Monster). Janis and Damian see Cady as a possible kindred spirit, the two adopt her as their own, becoming Cady’s first new friends at North Shore and, ultimately, partners in her plan to dethrone Regina George.